منابع مشابه
Integrin is on uPAR to unleash cells
To kill a brain cell he consequences of amyloid formation by the amyloid precursor protein (APP) in Alzheimer's disease (AD) have been the focus of many studies, yet little is known about the nonpathogenic function of APP. On page 27, some progress is made in this direction by Chen et al., who show that APP induces a suicide pathway in neurons. APP initiates this death-inducing cascade when it ...
متن کاملMicroenvironment and Immunology Trifunctional Bispecific Antibodies Induce Tumor-Specific T Cells and Elicit a Vaccination Effect
A major goal of tumor immunotherapy is the induction of long-lasting systemic T-cell immunity. Bispecific antibodies (bsAbs) that lack the immunoglobulin Fc region confer T–cell-mediated killing of tumor cells but do not induce long-termmemory. In contrast, trifunctional bsAbs comprise an appropriate Fc region and, therefore, not only recruit T cells but also accessory cells that bear activatin...
متن کاملTrifunctional bispecific antibodies induce tumor-specific T cells and elicit a vaccination effect.
A major goal of tumor immunotherapy is the induction of long-lasting systemic T-cell immunity. Bispecific antibodies (bsAbs) that lack the immunoglobulin Fc region confer T-cell-mediated killing of tumor cells but do not induce long-term memory. In contrast, trifunctional bsAbs comprise an appropriate Fc region and, therefore, not only recruit T cells but also accessory cells that bear activati...
متن کاملActivating natural killer (NK) cytotoxicity of canine CD5−CD21− cells requires low surface CD5 density NK cells
Natural killer (NK) cells play a crucial role in regulating immune functions. Few studies have characterized canine NK cells. We previously demonstrated that canine peripheral blood lymphocytes (PBLs) with a low surface CD5 density (CD5lo) are considered a critical NK population. Natural killer cells in most mammals do not express T-cell markers, but canine CD5lo cells express surface molecules...
متن کاملCD26+ Cord Blood Mononuclear Cells Significantly Produce B, T, and NK Cells
Background: Umbilical cord blood (UCB) is an alternative source of hematopoietic stem cell transplantation (HSCT), used in Leukemia treatment. CD26+ cells, a fraction of CD34 positive cells, are a major population of UCB cells which negatively regulate the in vivo homing and engraftment of HSCs. CD26 is highly expressed in various cells such as HSCs, immune cells, fibroblasts, and epithelial ce...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Reviews Immunology
سال: 2019
ISSN: 1474-1733,1474-1741
DOI: 10.1038/s41577-019-0188-6